Radial Spoke
Info Page Total Peptides Axo Count M+M Count KCl Count Terg Count 30 Min DeFlag (Fold Δ) XAP5 (Fold Δ) Human Homolog Gene and Aliases ChlamyFPv5 Annotation References: Annotation v5.6 Description
Cre06.g291700.t1.2 24 21 0 2 1 3.78 -2.39 RSPH3 RSP3; PF14 RSP3, Radial Spoke Protein 3 • Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
RSP3 | Flagellar radial spoke protein 3 (RSP3) [PMID: 16507594]; an axonemal A-kinase anchoring protein KAP [PMID: 11309423; PMID: 16571668; PMID: 16267272; GI:134041]. Gene originally termed PF14 [PMID: 7204490; PMID: 2745550; PMID: 2377611]
Cre03.g201900.t1.1 23 16 0 3 4 11.47 -2.98 RSPH1 RSP1 RSP1, Radial Spoke Protein 1 • Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
• Dimethylated on arginine (Mizuno and Sloboda 2017)
• Mice with a deletion of Rsph1 exhibit a low level of mucociliary clearance and develop a primary ciliary dyskinesia phenotype (Yin et al. Ostrowski 2019)
RSP1 | Flagellar protein, a subunit in the radial spoke head; C-terminus contains repeats of MORN motifs found in several membrane associated proteins [PMID: 16507594; GI:83284723]
Cre10.g427300.t1.2 23 14 2 0 7 8.46 -2.94 none RSP2; PF24 RSP2, Radial Spoke Protein 2 • Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
• Dimethylated on arginine (Mizuno and Sloboda 2017)
RSP2 | Radial spoke protein 2 (RSP2). Originally identified as PF24 locus [PMID: 16507594; PMID: 7204490; PMID: 14871938; GI:37528882]
Cre12.g511050.t1.2 20 8 1 1 10 15.05 -2.36 DNAJB13 RSP16; HSP40; PF33 RSP16, Radial Spoke Protein 16 • Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
• Radial spoke protein (Zhu et al. Yang 2018)
• Ciliary level increases during disassembly (Wang et al. Pan 2017)
• Mutants have altered radial spoke structure. Suggested to play roles in transport and folding of radial spokes (Zhu et al. Yang 2018)
RSP16 | A structural HSP40 (DnaJ) in the radial spoke stalk [PMID: 16507594, PMID: 15563613; GI:56404248]
Cre07.g330200.t1.2 17 7 0 1 9 13.9 -1.05 RSPH9 RSP9; PF17 RSP9, Radial Spoke Protein 9 • Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
• Ubiquitinated (Wang et al. Huang 2019)
RSP9 | A subunit in the flagellar radial spoke head; gene originally termed PF17 [PMID: 7204490, PMID: 16507594; GI:83284713]
Cre07.g347050.t1.2 15 9 0 3 3 14.35 -2.63 CALML5 RSP7 RSP7, Radial Spoke Protein 7 • Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
RSP7 | A subunit in the radial spoke stalk with multiple EF-hands tethered to an RIIa domain [PMID: 16507594; GI:83284725]
Cre12.g544000.t1.2 13 3 1 4 5 10.91 -1.72 none RSP5 RSP5, Radial Spoke Protein 5 • Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
• Dimethylated on arginine (Mizuno and Sloboda 2017)
RSP5 | A subunit in the radial spoke stalk, putative aldo/keto reductase [PMID: 16507594; GI:83284709
Cre02.g078600.t1.2 12 7 0 0 5 8.7 -2.6 none RSP8 RSP8, Radial Spoke Protein 8 • Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
RSP8 | An armadillo repeat protein in the radial spoke stalk [PMID: 16507594; GI:83284711]
Cre07.g340400.t1.2 12 7 0 0 5 14.55 EFCAB5 RSP17 RSP17, Radial Spoke Protein 17 • Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
RSP17 | A subunit in the radial spoke stalk; containing a coiled coil typical of filamentous polypeptides [PMID: 16507594; GI:83284727
Cre14.g617500.t1.2 12 3 0 0 9 9.92 -1.78 RSPH14 RSP14; FAP132 RSP14 (FAP132), Radial Spoke Protein 14 • Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
RSP14 | An Armadillo repeat protein in radial spoke stalk [PMID: 16507594]; Found in the flagellar proteome as FAP132 [PMID: 15998802]
Cre16.g654300.t1.2 12 11 0 0 1 16.18 -1.57 NME5 RSP23; NDK5 RSP23, Radial Spoke Protein 23; Similar to Nucleoside-Diphosphate Kinase • Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
• Flagellar Radial Spokes Contain a Ca2+-stimulated Nucleoside Diphosphate Kinase (Patel-King et al. King 2004 )
• General and Specific Promotion of Flagellar Assembly by a Flagellar Nucleoside Diphosphate Kinase (Zhu et al. Yang 2017 )
• Mutations in Nme5 cause primary ciliary dyskinesia in alaskan malamuts and hydrocephalus along with sperm flagellar defects in mice (Anderegg et al. Leeb 2019)
• A Nonsense Variant in NME5 Causes Human Primary Ciliary Dyskinesia With Radial Spoke Defects (Cho et al. Ki 2020)
RSP23 | RSP23, a spoke specific nucleotide diphosphate kinase [PMID: 16507594; PMID: 15194815; GI:42412387]
Cre10.g465250.t1.2 8 5 0 0 3 14.6 -2.07 ROPN1L RSP11; PF25 RSP11, Radial Spoke Protein 11 • Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
RSP11 | Flagellar radial spoke protein 11 (RSP11) at radial spoke stalk; containing an RIIa domain initially found in the regulatory subunit of cAMP dependent protein kinase. Gene originally termed PF25 [PMID: 16507594; PMID: 7204490; PMID: 16267272; GI:83284717]
Cre05.g242500.t1.2 8 3 0 0 5 9.92 -2.03 RSPH6A RSP4; PF1 RSP4, Radial Spoke Protein 4 • Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
• Loss of Rsph6a causes male sterility in mouse. Not clear if Rsph6a is orthologous to Rsp4 or Rsp6 (Abbasi et al. Ikawa 2018)
• Rsph4a Is Essential for the Triplet Radial Spoke Head Assembly of the Mouse Motile Cilia. Not clear if Rsph4a is orthologous to Rsp4 or Rsp6 (Yoke et al. Shinohara 2020)
RSP4 | Flagellar radial spoke protein 4 (RSP4), a component of the radial spoke head; gene originally termed PF1 [PMID: 7204490; PMID: 1508197; PMID: 16507594; GI:401050]
Cre05.g242550.t1.2 8 2 0 2 4 13.07 -2.29 RSPH4A RSP6; PF26 RSP6, Radial Spoke Protein 6 • Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
• Dimethylated on arginine (Mizuno and Sloboda 2017)
• Loss of Rsph6a causes male sterility in mouse. Not clear if Rsph6a is orthologous to Rsp4 or Rsp6 (Abbasi et al. Ikawa 2018)
• Rsph4a Is Essential for the Triplet Radial Spoke Head Assembly of the Mouse Motile Cilia. Not clear if Rsph4a is orthologous to Rsp4 or Rsp6 (Yoke et al. Shinohara 2020)
RSP6 | Flagellar radial spoke protein 6; gene originally termed PF26 [PMID: 16507594; PMID: 7204490; PMID: 1508197; GI:401051]
Cre03.g178150.t1.1 8 2 2 2 2 2.83 CALM2 CAM1; RSP20 CAM1, Calmodulin 1; Radial Spoke Component • Radial Spoke Subunit (Wargo et al. Smith 2005)
• Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
• Transition Zone Protein (4 spectral counts [Diener et al. Rosenbaum 2015])
CAM1 | identical to CALM_CHLRE; contains 4 EF-hand, calcium binding motifs; Calmodulin mediates the control of a large number of enzymes by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatas
Cre03.g181150.t1.1 7 4 2 1 0 7.66 DYNLL1 ; DYNLL12 DLL1; ODA-LC8; RSP22; FLA14 DLL1 (ODA-LC8 | RSP22), Light Chain Associated with Outer Arm Dynein, Cytoplasmic Dynein 1b, Inner Arm Dynein I1/f and Radial Spokes • Conserved light chain found in several dynein motors (King et al. Patel-King 1995 )
• Subunit of the retrograde IFT dynein motor. Mutant cilia are short and filled with IFT particles (Pazour et al. Witman 1998)
• A Unified Taxonomy for Ciliary Dyneins (Hom et al. King 2011)
• Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
• TCTEX1D2 Mutations Underlie Jeune Asphyxiating Thoracic Dystrophy With Impaired Retrograde Intraflagellar Transport (Schmidts et al. Witman 2015)
• The mutation in PF5 strain CC1331 is allelic to DLL1 but the mutation in PF5 strain CC1028 is not allelic. The defective gene in CC1028, presumptive to be the bona fide PF5, remains to be identified (Pinfen Yang)
• Transition Zone Protein (4 spectral counts [Diener et al. Rosenbaum 2015])
• Ubiquitinated (Wang et al. Huang 2019)
• Centriolar Protein (Hamel et al. Gonczy 2017)
FLA14 | LC8 component of outer arm dynein, inner arm I1/f and RSP22 of radial spokes [PMID: 7744782; PMID: 9585416]; Matsuo et al. 28 [PMID: 18334618] reported that the roc16 (rhythm of chloroplast) circadian rhythm mutant locus maps here; the mutation in CC-13
Cre01.g005450.t1.2 6 3 0 0 3 9.8 -2.55 RSPH1 RSP10 RSP10, Radial Spoke Protein 10 • Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
• Ubiquitinated (Wang et al. Huang 2019)
RSP10 | A subunit in the radial spoke head with multiple MORN motifs [PMID: 16507594; GI:83284715]
Cre02.g114700.t1.2 5 3 0 0 2 8.8 PPIL6 RSP12; CYN17 RSP12, Radial Spoke Protein 12; Peptidyl-prolyl cis-trans isomerase; cyclophilin-type • Radial Spoke Proteins of Chlamydomonas Flagella (Yang et al. Witman 2006)
RSP12 | peptidyl-prolyl cis-trans isomerase, cyclophilin-type; found in the flagellum radial spoke stalk (RSP12) [PMID: 16507594]
© Gregory J. Pazour