Dynein Regulatory Complex
Info Page Total Peptides Axo Count M+M Count KCl Count Terg Count 30 Min DeFlag (Fold Δ) XAP5 (Fold Δ) Human Homolog Gene and Aliases ChlamyFPv5 Annotation References: Annotation v5.6 Description
Cre14.g612700.t1.2 41 34 0 1 6 10.54 DRC7 DRC7; FAP50; CFAP50 DRC7 (FAP50), dynein regulatory complex 7 • The N-DRC Forms a Conserved Biochemical Complex That Maintains Outer Doublet Alignment and Limits Microtubule Sliding in Motile Axonemes (Bower et al. Porter 2013)
• Building Blocks of the Nexin-Dynein Regulatory Complex in Chlamydomonas Flagella (Lin et al. Nicastro 2011)
• conserved; Drosophila CG34110/Ccdc135/FAP50 (Yang et al. Lu 2011)
• Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex (Gui et al. Nicastro 2019)
• Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice (Morohoshi et al. Ikawa 2020)
DRC7 | found in the flagellar proteome; Possible serine/threonine protein kinase or adenylate kinase
AFU81554.1 30 22 0 1 7 DRC1 DRC1; PF3 DRC1, Dynein Regulatory Complex 1 • Dynein regulatory complex subunit (Wirschell et al. Omran 2013)
• Not in the Phytozome Genome Assembly GenBank Data
• Copy number variation in DRC1 is the major cause of primary ciliary dyskinesia in the Japanese population (Takeuchi and Nakatani 2020)
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Cre07.g325762.t1.1 26 20 0 0 6 -1.33 IQCA1 DRC11; FAP82; FBB15 DRC11 (FAP82), dynein regulatory complex 11 • The N-DRC Forms a Conserved Biochemical Complex That Maintains Outer Doublet Alignment and Limits Microtubule Sliding in Motile Axonemes (Bower et al. Porter 2013)
• Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex (Gui et al. Nicastro 2019)
DRC11 | Conserved uncharacterized Flagellar Associated Protein; found in the flagellar proteome; identified in the flagellar basal body proteome as FBB15 [PMID: 15137946]; upregulated by deflagellation
Cre11.g476850.t1.2 17 13 0 2 2 10.4 GAS8 DRC4; PF2; GAS8 DRC4 (PF2), Dynein Regulatory Complex Protein 4 • A Subunit of the Dynein Regulatory Complex in Chlamydomonas Is a Homologue of a Growth Arrest-Specific Gene Product (Rupp and Porter 2003)
• Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex (Gui et al. Nicastro 2019)
DRC4 | Component (DRC4) of dynein regulatory complex (DRC) of flagellar axoneme, originally identified by pf2 mutation; has similarity to mammalian growth-arrest specific gene product (Gas11/Gas8); component of dynein regulatory complex (DRC) of flagellar axonem
Cre13.g607750.t1.2 17 12 0 0 5 7.88 CCDC65 DRC2; FAP250; CCDC65; IDA6; CFAP250 DRC2 (FAP250), dynein regulatory complex 2; Similar to NYD-SP28 • The N-DRC Forms a Conserved Biochemical Complex That Maintains Outer Doublet Alignment and Limits Microtubule Sliding in Motile Axonemes (Bower et al. Porter 2013)
• Building Blocks of the Nexin-Dynein Regulatory Complex in Chlamydomonas Flagella ( Lin et al. Nicastro 2011)
• pf3; conserved; methylated (Werner-Peterson and Sloboda 2013)
• PCD (Austin-Tse et al Hildebrandt 2013)
• Mutations disrupt the assembly of several other N-DRC subunits and also destabilizes the assembly of several closely associated structures such as the inner dynein arms, the radial spokes, and the calmodulin- and spoke-associated complex (Bower et al Porter 2018)
• Dimethylated on arginine (Mizuno and Sloboda 2017)
DRC2 | Flagellar Associated Protein; found in the flagellar proteome; identified in the flagellar basal body proteome [PMID: 15137946]; upregulated by deflagellation; Similar to NYD-SP28
Cre02.g141350.t1.2 15 5 0 3 7 3.33 IQCD DRC10; FAP84; CFAP84 DRC10 (FAP84), dynein regulatory complex 10 • The N-DRC Forms a Conserved Biochemical Complex That Maintains Outer Doublet Alignment and Limits Microtubule Sliding in Motile Axonemes (Bower et al. Porter 2013)
DRC10 | Flagellar Associated Protein, found in the flagellar proteome
Cre01.g045350.t1.2 12 4 0 0 8 12.39 TCTE1 DRC5; FAP155 DRC5 (FAP155), dynein regulatory complex 5 • The N-DRC Forms a Conserved Biochemical Complex That Maintains Outer Doublet Alignment and Limits Microtubule Sliding in Motile Axonemes (Bower et al. Porter 2013)
• Building Blocks of the Nexin-Dynein Regulatory Complex in Chlamydomonas Flagella (Lin et al. Nicastro 2011)
• Gene deleted in pf4, conserved
• Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex (Gui et al. Nicastro 2019)
• TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa (Castaneda et al. Liu 2017)
• Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice (Morohoshi et al. Ikawa 2020)
DRC5 | (PubMed ID:23427265 Bower et al. Porter 2013) and (PubMed ID:21700706 Lin et al. Nicastro 2011); gene deleted in pf4; conserved
Cre01.g025450.t1.2 10 5 0 1 4 3.54 IQCG DRC9; FAP122; CFAP122 DRC9 (FAP122), dynein regulatory complex 9 • The N-DRC Forms a Conserved Biochemical Complex That Maintains Outer Doublet Alignment and Limits Microtubule Sliding in Motile Axonemes (Bower et al. Porter 2013)
• HA-tagged (Lechtreck et al. Witman 2009)
DRC9 | Flagellar Associated Protein, found in the flagellar proteome; phosphorylation characterized by Boesger et al. (29) [PMID: 19429781]
Cre12.g531500.t1.2 9 6 0 0 3 10.44 DRC3 DRC3; FAP134; CFAP134 DRC3 (FAP134), dynein regulatory complex 3 • The N-DRC Forms a Conserved Biochemical Complex That Maintains Outer Doublet Alignment and Limits Microtubule Sliding in Motile Axonemes (Bower et al. Porter 2013)
• Building Blocks of the Nexin-Dynein Regulatory Complex in Chlamydomonas Flagella (Lin et al. Nicastro 2011)
• HA-tagged, (Lechtreck et al. Witman 2009)
• DRC3 Connects the N-DRC to Dynein G to Regulate Flagellar Waveform (Awata et al. Witman 2015)
DRC3 | Found in the flagellar proteome; identified in the flagellar basal body proteome [PMID: 15137946]; upregulated by deflagellation
Cre16.g676645.t1.1 5 2 0 0 3 4.4 EFCAB2 DRC8; FAP200; CFAP200 DRC8 (FAP200), dynein regulatory complex 8 • The N-DRC Forms a Conserved Biochemical Complex That Maintains Outer Doublet Alignment and Limits Microtubule Sliding in Motile Axonemes (Bower et al. Porter 2013)
• Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex (Gui et al. Nicastro 2019)
DRC8 | Flagellar Associated Protein, found in the flagellar proteome [PMID: 15998802]
© Gregory J. Pazour