Central Pair
Info Page Total Peptides Axo Count M+M Count KCl Count Terg Count TM Helices, Lipid Mod 30 Min DeFlag (Fold Δ) XAP5 (Fold Δ) Human Homolog Gene and Aliases ChlamyFPv5 Annotation References: Annotation v5.6 Description
Cre01.g025400.t1.2 60 37 0 4 19 0 11.2 HYDIN HYDIN; HYD3 HYD3, Hydrocephalus 3-Like Protein Hydin (Lechtreck and Witman 2007) HYDIN  |  hydrocephalus-inducing protein homolog, forms extension C2b of axonemal central pair
Cre03.g183200.t1.2 54 36 1 5 12 0 10.17 -2.3 SPEF2 CPC1 CPC1, Central Pair 1 (Zhang and Mitchell 2004) CPC1  |  Mutations at CPC1 disrupt assembly of a central pair microtubule-associated complex and alter flagellar beat frequency in Chlamydomonas [PMID: 15292403]. Identified in the flagellar and basal body proteome as FBB7 [PMID: 15137946]; upregulated by deflagel
Cre12.g519950.t1.1 47 37 0 4 6 0 9.42 -3.44 GUK1 FAP42; C1b-350; GUK3 FAP42, Flagellar Associated Protein 42; C1b-350 component of C1b projection on central pair C1b-350 component of C1b projection on central pair (Mitchell et al. Mitchell 2005) FAP42  |  Found in the flagellar proteome; contains N-terminal calpain cysteine endopeptidase domain; null-allele mutant was isolated (PMID 29743196); C1b-350 component of C1b projection on central pair
Cre10.g434400.t1.2 37 27 0 3 7 0 10.48 -1.82 none PF6 PF6, Central Pair Protein PF6 (Rupp et al. Porter 2001) PF6  |  Together with C1a-86, C1a-34, C1a-32, C1a-18, and calmodulin, forms the central pair projection C1a; may play a role in modulating both inner and outer dynein arm activity
Cre10.g420800.t1.1 30 25 0 0 5 0 6.56 CFAP46 FAP46; C1d-HC2; CFAP46 FAP46, Flagellar Associated Protein 46; HC2 of C1d projection on central pair HC2 of C1d projection on central pair (DiPetrillo and Smith 2010) FAP46  |  Found in the flagellar proteome [PMID: 15998802]; together with FAP221,FAP54, FAP74, C1d-87 and calmodulin, form a single complex in the C1d projection NULL NULL FAP46 20421426 C1d-HC2 Flagellar Associated Protein 46
Cre12.g518550.t1.1 22 21 0 0 1 0 6.52 -1.34 CFAP54 FAP54; C1d-HC1; CFAP54 FAP54, Flagellar Associated Protein 54; HC1 of C1d projection on central pair HC1 of C1d projection on central pair (DiPetrillo and Smith 2010) FAP54  |  found in the flagellar proteome [PMID: 15998802]; identified in the flagellar basal body proteome [PMID: 15137946]; upregulated by deflagellation; together with FAP221, FAP46, FAP74, C1d-87 and calmodulin, form a single complex in the C1d projection; HC1
Cre03.g168200.t1.2 20 16 0 0 4 0 8.39 -2.17 CFAP69 FAP69; C1b-135; CFAP69 FAP69, Flagellar Associated Protein 69; C1b-135 component of C1b projection on central pair C1b-135 component of C1b projection on central pair (Mitchell et al. Mitchell 2005); Mutations in humans and mice cause severe asthenoteratospermia with multiple morphological abnormalities of the sperm flagella (Dong et al. Coutton 2018) and (He et al. Cao 2018) FAP69  |  Conserved Flagellar Associated Protein
Cre03.g167600.t1.2 19 16 0 1 2 0 11.39 -2.81 CFAP61 FAP61; CaM-IP3; CFAP61 FAP61, Flagellar Associated Protein 61; CaM-IP3; Associated with the CaM- and spoke-Associated CSC complex at the base of the radial spoke; altered in DRC mutant axonemes; conserved CaM-IP3, associated with the CaM- and spoke-associated CSC complex at the base of the radial spoke (Dymek and Smith 2007); altered in DRC mutant axonemes ( Lin et al. Nicastro 2011); conserved; basal structure of RS3 (Urbanska et al Wloga 2015) FAP61  |  Associated with the CaM- and spoke-Associated CSC complex at the base of the radial spoke; altered in DRC mutant axonemes; conserved Flagellar Associated Protein; identified in the flagellar basal body proteome [PMID: 15137946]; basal structure of RS3 (Pu
Cre06.g271150.t1.1 18 15 0 0 3 0 9.08 -1.82 CFAP74 FAP74; C1d-HC3; CFAP74 FAP74, Flagellar Associated Protein 74; HC3 of C1d projection on central pair HC3 of C1d projection on central pair (DiPetrillo and Smith 2010) FAP74  |  found in the flagellar proteome [PMID: 15998802]; HC3 of C1d projection on central pair (PubMed ID:20421426 DiPetrillo and Smith, 2010); together with FAP221, FAP46, FAP54, C1d-87 and calmodulin, form a single complex in the C1d projection
Cre03.g185650.t1.2 17 13 0 0 4 0 11.85 -1.9 WDR66 FAP251; CaM-IP4; CFAP251; WDR66 FAP251, Flagellar Associated Protein 251; CaM-IP4; Associated with the CaM- and spoke-Associated CSC complex at the base of the radial spoke CaM-IP4, associated with the CaM- and spoke-associated CSC complex at the base of the radial spoke (Dymek and Smith 2007); basal structure of RS3 (Urbanska et al. Wloga 2015); mutations lead to male infertility in humans (Auguste et al. Mitchell 2018)(Li et al. Cao 2018) FAP251  |  Flagellar Associated Protein; found in the flagellar proteome; identified in the flagellar basal body proteome [PMID: 15137946]; upregulated by deflagellation; associated with the CaM- and spoke-Associated CSC complex at the base of the radial spoke
Cre04.g227900.t1.2 14 0 1 11 2 0 13.1 -2.61 SPAG16 PF20 PF20, Central Pair Associated WD-Repeat Protein (Smith and Lefebvre 1997) PF20  |  WD-repeat containing protein PF20 of the central pair of the flagella; associates with the intermicrotubule bridge; may contain additional coding sequence in intronic N-island PMID: 27175017
Cre11.g476376.t1.1 13 12 0 0 1 0 8.7 CFAP221 FAP221; Pcdp1; CFAP221 FAP221, Coiled-Coil Flagellar Associated Protein 221; HC4 of C1d projection on central pair; very Similar to FAP360 - not clear if this is a recent gene duplicatoin or an assembly artifact; Similar to mammalian primary ciliary dyskinesia protein 1 (Pcdp1) Pcdp1: HC4 of C1d projection on central pair (DiPetrillo and Smith 2010) FAP221  |  HC4 of C1d projection on central pair; Similar to mammalian primary ciliary dyskinesia protein 1 (Pcdp1); this gene model is probably a fusion between RNA polymerase III subunit RPC82 and a protein very similar to FAP221 Cre49.g761347, probably due to an
Cre06.g256450.t1.2 11 8 0 2 1 0 11.85 -2.53 CCDC189 FAP119; C1a-34; PF6-IP2 FAP119, Flagellar Associated Protein 119; C1a-34; C1a projection on central pair C1a-34, C1a projection on central pair (Wargo et al. Smith 2005); pI shift in DRC mutants (Lin et al. Nicastro 2011); Ciliary level increases during disassembly (Wang et al. Pan 2017) FAP119  |  also known as C1a-34; form the C1a projection, with PF6, C1a-86, C1a-32, C1a-18, and calmodulin; similar to C1a-32; may play a role in modulating both inner and outer dynein arm activity; pI shift in DRC mutants (PubMed ID:21700706 Lin et al. Nicastro 20
Cre07.g330700.t1.2 11 6 0 0 5 0 5.27 -2.28 MAATS1 FAP91; Cam-IP2; CFAP91 FAP91, Flagellar Associated Protein 91; Cam-IP2; Associated with the CaM- and spoke-Associated CSC complex at the base of the radial spoke; Similar to Sperm cAMP-Dependent Protein Kinase Associated Protein AAT1 Cam-IP2, associated with the CaM- and spoke-associated CSC complex at the base of the radial spoke (Dymek and Smith, 2007) FAP91  |  Flagellar Associated Protein similar to sperm protein kinase associated protein AAT1. Found in the flagellar proteome, upregulated by deflagellation [PMID: 15998802]; identified in the flagellar and basal body proteome as FBB8 [PMID: 15137946]; Associated
Cre09.g389282.t1.1 11 4 0 0 7 0 7.34 -2.39 CCDC189 FAP114; C1a-32; PF6-IP3 FAP114, Coiled-Coil Flagellar Associated Protein 114; C1a-32; C1a projection on central pair C1a-32, C1a projection on central pair (Wargo et al. Smith 2005); Ciliary level increases during disassembly (Wang et al. Pan 2017) FAP114  |  also known as C1a-32; forms the C1a projection, with PF6, C1a-86, C1a-34, C1a-18, and calmodulin; similar to C1a-34; may play a role in modulating both inner and outer dynein arm activity
Cre49.g761347.t1.1 11 9 0 0 2 0 11.2 CFAP221 FAP360; FAP221L; Pcdp1 FAP360, Flagellar Associated Protein 360; very Similar to FA221 - not clear if this is a recent gene duplicatoin or an assembly artifact; Similar to mammalian primary ciliary dyskinesa protein 1 (Pcdp1) FAP360  |  flagella protein of the C1d central pair projection; similar to PRIMARY CILIARY DYSKINESIA PROTEIN 1 (PCDP1); bind calmodulin in high CA2+; N-terminus is homologous to that of Hydin; very Similar to FAP221 - not clear if this is a recent gene duplicatoin
Cre02.g112100.t1.1 10 6 0 0 4 0 6.69 -1.31 TCTE1 FAP101; C1a-86; PF6-IP1 FAP101, Flagellar Associated Protein 101; C1a-86; C1a projection on central pair C1a-86 , C1a projection on central pair (Wargo et al. Smith 2005) FAP101  |  Flagellar Associated Protein with weak similarity to a kinase regulatory subunit; also known as C1a-86; form the C1a projection, with PF6, C1a-34, C1a-32, C1a-18, and calmodulin; may play a role in modulating both inner and outer dynein arm activity
Cre09.g394251.t1.1 8 3 0 5 0 0 12.13 -2.36 SPAG6 PF16 PF16, Central Pair Protein PF16 (Smith and Lefebvre 1996) PF16  |  NULL
Cre02.g105950.t1.2 7 5 0 2 0 0 9.63 -1.42 MYCBP FAP174 FAP174, Flagellar Associated Protein 174; AKAP interactor in the central pair AKAP interactor in the central pair (Rao et al. D'Souza 2016) FAP174  |  MYCBP-1 homolog; AKAP interactor in the central pair; found in the flagellar proteome, interacts with AKAP240 to regulate ciliary beating
Cre17.g729850.t1.2 7 2 0 1 4 0 9.51 MORN2 FAP227; C1a-18; PF6-IP4 FAP227, Flagellar Associated Protein 227; C1a-18, C1a projection on central pair; Similar to Testis Specific Gene A2 C1a-18, C1a projection on central pair (Wargo et al. Smith 2005) FAP227  |  Similar to Testis Specific Gene A2; Together with PF6, C1a-86, C1a-34, C1a-32 and calmodulin, forms the central pair projection C1a; may play a role in modulating both inner and outer dynein arm activity; Similar to Sjoegren syndrome nuclear autoantigen
Cre01.g029350.t1.2 2 1 0 0 1 0 6.83 -1.65 WDR93 FAP297; C1d-87 FAP297, WD40-Repeat Containing Coiled-Coil Flagellar Associated Protein 297; C1d-87 projection on central pair C1d-87 projection on central pair (Brown et al. Witman 2012) FAP297  |  contains WD40 repeats; found in the flagellar proteome [PMID: 15998802]; together with FAP221, FAP46, FAP54, FAP74 and calmodulin, form a single complex in the C1d projection
© Gregory J. Pazour