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| ChlamyFPv5 (gene name | annotation): PACRG | "Parkin Co-Regulated Gene Protein" |
| Aliases: PACRG |
| Structure: Axoneme | |
| References: |
| •Axonemal localization of Chlamydomonas PACRG, a homologue of the human Parkin-coregulated gene product (Ikeda et al. Kamiya 2007) |
| •Microtubule binding protein PACRG plays a role in regulating specific ciliary dyneins during microtubule sliding (Mizuno et al. Smith 2016) |
| •Transition Zone Protein (2 spectral counts [Diener et al. Rosenbaum 2015]) |
| •PACRG and FAP20 form the inner junction of axonemal doublet microtubules and regulate ciliary motility (Dymek et al. Smith 2019) |
| •Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable)mouse mutant (Lorenzetti et al. Justice 2004) |
| •The Parkin co-regulated gene product, PACRG, is an evolutionarily conserved axonemal protein that functions in outer-doublet microtubule morphogenesis (Dawe et al. Gull 2005) |
| •Deletion of the Parkin co-regulated gene causes defects in ependymal ciliary motility and hydrocephalus in the quakingviable mutant mouse (Wilson et al. Lockhart 2010) |
| •Generation and characterisation of a parkin-Pacrg knockout mouse line and a Pacrg knockout mouse line (Stephenson et al. Lockhart 2018) |
| •Outer doublet microtubule inner luminal protein (MIP) associated with the inner junction. Repeats with 8 nm periodicity (Ma et al. Zhang 2019) |
| •The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications (Khalifa et al. Bui 2020) |
| •Subunit of the axonemal IJ protofilament (IJ PF) (Khalifa et al. Bui 2020) |
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| CrFP Total Peptides = 20 (9 Axonemal Peptides | 0 M+M Peptides | 2 KCl Peptides | 9 Tergitol Peptides) |
| Wang Peptides (Wang et al. Pan 2017) = 8 (enriched 1 fold by ciliary shortening) |
| Jordan Peptides (Jordan et al. Pigino 2018) = Wild Type M+M: 3 | Dhc1b-3 M+M: 3 | Ift139-2 M+M: 3 (Total Unique Peptides) |
| Picariello Peptides (Picariello et al. Witman 2019) = Wild Type M+M: 9 | Ift140 ΔN-terminal WD repeat M+M: 14 (Total Unique Peptides) |
| Zhao Central Apparatus Project (Zhao et al. Witman 2019) = Wild Type Axo: 124 | Pf18 Axo: 132 (Total Unique Peptides, summed from two biological replicates for each. Proteins found only in this dataset needed 10 or more peptides to be included) |
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| Phytozome (gene name | defline): | 1 |
| Annotation v5.6 Symbol | Defline: | Parkin Co-Regulated Gene Protein |
| Annotation v5.6 Description: NULL |
| Annotation v5.6 Synonyms: Cre02.g113400.t1.1#g2336.t1#BUG21 |
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| Steve King Dynein Anotation: (no data) | (no data) |
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| Yuqing Hou's Human Homologs: PACRG, (no data), (no data) (Blast E value: (no data) | Reprocal Best Match? (no data)) |
| Albee et al. Dutcher 2013 Human Homolog: PACRG, parkin coregulated gene protein isoform 2 |
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| Lipid Modifications (N-Myristoylation: MGXXXS/T, S-Geranylgeranylation: CAAX , S-Geranylgeranylation: CC/CXC, S-Farnesylation: CAAX predicted by GPS-Lipid): (no data) |
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| Fold Upregulated Post Deflagellation (Albee et al. Dutcher 2013) at 3 min: 8.62; at 10 min: 13.1; at 30 min: 10.51; at 60 min: 3.1 |
| Importance of XAP5 for expression (Li et al. Hu 2018) Wild Type: 4764.75 FPKM | XAP Mutant: 1459.61 FPKM | Fold Change: -1.71 |
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| CLIP Library: Cre02.g113400 |
| Phytozome Transcript: Cre02.g113400.t1.2 |
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